Cholecalciferol


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ABSTRACT

Vitamin D metabolizing enzymes and vitamin D receptors are present in many cell types including various immune cells such as antigen-presenting-cells, T cells, B cells and monocytes. In vitro data show that, in addition to modulating innate immune cells, vitamin D also promotes a more tolerogenic immunological status. In vivo data from animals and from human vitamin D supplementation studies have shown beneficial effects of vitamin D on immune function, in particular in the context of autoimmunity. In this review, currently available data are summarized to give an overview of the effects of vitamin D on the immune system in general and on the regulation of inflammatory responses, as well as regulatory mechanisms connected to autoimmune diseases particularly in type 1 diabetes mellitus.


This page is under preparation



Vitamin D3 (cholecalciferol) – essential for the immune health

Prietl B, Treiber G, et al: Vitamin D and Immune Function; Nutrients 2013, 5, 2502-2521; doi:10.3390/nu5072502

Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria; E-Mails: barbara.prietl@medunigraz.at (B.P.); gerlies.treiber@medunigraz.at (G.T.); endo@medunigraz.at (T.R.P.)

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